LABORATORY FEATURES
CLL
CML
Panmyelosis
Myeloid
cell predominate
Malignant
cell types:
Pb
looks like bm aspirate
Small,
mature lymphocytes
B-cell
phenotype
Smudge
cells present
SIg
weakly positive
50-500
x 109/L
leukocytes
<10%
blasts in pb
Pseudo-Pelger-Hüet
cells present
Twinning
present in segs
Course
granulation makes it hard:
To
tell progranulocytes from basophils
LAPA:
0 to
slightly increased
N/N
anemia
All
cell lines increased
>10
x 109/L
lymphocytes
>30%
bm nucleated cells lymphoblasts
Light
chains expressed
CD5
(a T-cell marker) positive
If
<10 x 109/L
lymphocytes then:
Bm
involvement & immunophenotyping must confirm
CLL
N/N
anemia
Thrombocytopenia
nRBCs
may be seen
Pseudo-Gaucher
cells present