Hairy Cell Leukemia (HCL)
Incidence:
Cell lines involved:
Rare
disorder accounting for 2% of leukemias
Middle-aged
(avg. 50 years)
Mid-to-late
B-cells
Clinical features:
Splenomegaly
in 80% of cases
Pancytopenia
– classic feature
“Dry-tap”
bone marrow aspirate
TRAP
positive:
Tartrate
resistant acid phosphatase positive
Cell
phenotype:
SIg
and CIg positive
PCA-1
antigen positive
7
year median survival
Prognosis: