Polycythemia Vera (PV)-1
Pathophysiology:
A
clonal process in a pluripotential hematopoietic stem cell
resulting in a clone of cells that is hypersensitive to
erythropoietin resulting in increased erythroid production
Polycythemia
rubra vera (PRV)
Alternate name:
Clinical features:
80%
manifest panmyelocytosis of bone marrow
100%
of bone marrow volume involved in hematopoiesis
Normal
cell morphology in bone marrow & pb.
Splenomegaly
& hepatomegaly
Hemorrhaging
may be present
Thrombosis
may also be seen