Agnogenic Myeloid Metaplasia-1
Pathophysiology:
A
clonal disorder with ineffective hematopoiesis which results
in hypercellularity, increased megakaryocytes, marrow
fibrosis, immature granulocytes & erythrocytes, and
poikilocytosis in pb, and splenomegaly.
Seen
more commonly in older age group
Incidence:
Marrow
hypercellularity
Lab features:
Increased
megakaryocytes – large and atypical
Increased
fibrosis of bone marrow
Increased
number of immature granulocytes in pb
Increased
number of erythroblasts in pb
Increased
number of poikilocytes in pb (dacryocytes)
Variable
blood picture