Agnogenic Myeloid Metaplasia-2
Myelofibrosis:
Clinical features:
Type
I, III, and IV collagen present
Extramedullary
hematopoiesis results in:
Immune
response:
50%
have humoral immune response abnormalities such as:
Autoantibodies (RBC,
nuclear, g-globulins)
Circulating immune
complexes (C’)
May
also be seen in benzene & radiation injury to bone
marrow
Hepatomegaly
& splenomegaly
Results
when clonal cells released from bm get established in these
organs
amyloidosis