CLSC411

Reed-Sternberg & Variants

Reed-Sternberg cell:

Thick walled, binucleated, with large eosinophilic nucleoli giving it an “owl eyes” appearance

Seen in highest numbers in mixed cellularity subtype

Mononuclear variant of RS cell

Large, multilobated nuclei with inconspicuous nucleoli

Hodgkin cell:

Lacunar cell:

Usually seen in nodular sclerosis subtype

Polylobated or Lymph/Histiocyte variant:

Large cells with polylobated nuclei (“popcorn cell”)

Usually seen in nodular lymphocyte predominance subtype

Pleomorphic or Anaplastic variant:

Large cells with angular, variable sized, hyperchromatic nuclei and scant cytoplasm

Seen in lymphocyte depletion subtype