MGUS
Definition:
Monoclonal
Gammopathy of Uncertain
Significance
Presence
of circulating monoclonal proteins without associated
plasma cell dyscrasia.
Pathophysiology:
Incidence:
3%
of all adults >70 years of age have it
Diagnosis:
<10%
plasmacytosis in bone marrow
Increase
levels of immunoglobulins
Prognosis:
15%
transform to multiple myeloma after 10 years