Burkitt Lymphoma
Diffuse
proliferation of small neoplastic lymphoid cells intermingled
with lighter staining histiocytes giving a “starry-sky”
appearance to biopsies
Pathophysiology:
Incidence:
Seen
in both children and adults and adults with AIDS
Two variants:
African/endemic:
American/sporadic:
7
year olds with large jaw mass
Older
children and adults with large abdominal mass
Viral association:
EBV
nucleic acid recovered in 80% of Burkitt cases
Cell lineage:
Mature
B-cells