Myelodysplastic Syndrome - 2
Main
group at risk are >50 year olds
Incidence:
A
few cases seen in younger adults and children
Types of MDS:
Primary
MDS:
Therapy-related
MDS:
Hereditary
MDS:
Inherited
defects
t-MDS
or TR-MDS
Over
again or anew
Etiology of MDS:
Proposed
that a disruption of apoptosis may be responsible
for the ineffective hematopoiesis seen in MDS.
Contributing factors may be:
Environmental
exposure
Chemical
insults
Radiation
exposure
Smoking
Viral
infections