Treatment-MDS
MDS
seen in patients who have been previously treated
with chemotherapy and/or radiotherapy
Pathophysiology:
Incidence:
Onset
varies depending on therapy but median time is:
2.5
– 5 years post-therapy initiation
Features of t-MDS:
More
aggressive
May
quickly evolve into AML
Very
severe dysplastic changes in pb and bm
Ringed
sideroblasts
Hypocellularity
Myelofibrosis
Abnormalities
in chromosome 5 and/or 7