Dysmyelopoiesis - 1
Persistent basophilic cytoplasm:
Peripheral blood features:
Abnormal granulation:
Abnormal nuclear shape:
Indicates nuclear-cytoplasm asynchrony
Hypo/hypersegmentation, nuclear rings
Large, hypogranulation, or absence of granules
Bone marrow features:
Uneven cytoplasmic staining:
Dense ring of basophilia around edge of cell with clear zone around nucleus
Abnormal granulation:
No primary granules in promyelocyes or myelocytes
Occassional Auer rod lead to error of AML