CLSC411

Cytogenetics & Molecular Genetics

Chromosomal abnormalities:

Occur in:

Most common chromosomes involved are:

Most common single abnormalities are:

Less common abnormalities are:

40 – 70% of de novo MDS

5, 7, 8, and 20

5q- and monosomy 7

12p-, ios 17, -22, loss of Y chromosome

Up to 90% of t-MDS

Molecular abnormalities:

Specific oncogenes responsible for mutations are:

ras family, p53, c-fms, IF regulator factor-1, and bcl-2