Vascular factors affecting Fibrinolysis
Tissue
Plasminogen Activator (t-PA):
Secreted
by endothelial cells
Binds
with polymerized fibrin
Activates
plasminogen to plasmin
Plasminogen
Activator Inhibitor – 1 (PAI-1)
Secreted
by endothelial cells
Neutralizes
free t-PA