Platelet Aggregation
Endothelial
cells damaged
Collagen-rich
basement membrane exposed
Platelets drawn into damaged area by increased turbulence
If
damage is moderate to severe:
Platelets stick to each other
They expend their energy stores
Once
aggregated platelets can not disaggregate
Platelets
shed phospholipids and coagulation proteins
In order for aggregation to take place the following are required:
Their membrane integrity lost
Form an unstructured mass called “syncytium”
Von Willebrand factor & fibrinogen
Steps involved: