Zymogens-Anticoagulants-Cofactors
Prothrombin
Pre-kallikrein
Protein S
Heparin cofactor II
XIII
Thrombomodulin
Alpha-2 macroglobulin
XII
Tissue factor
Alpha-1 antitrypsin
XI
HMWK
Antithrombin
X
VIII
Protein C
IX
V
TFPI
VII
COFACTORS
ANTICOAGULANTS
ZYMOGENS
Fibrinogen is a substrate
HMWK = high molecular weight kininogen
TFPI = tissue factor pathway inhibitor