Vitamin K
Factors that
require vitamin K for synthesis:
Factor
VII
Factor
IX
Factor
X
Protein
C
Required for the addition of a g-carbon to glutamic acid to form g-carboxyglutamic
acid
The g-carboxyglutamic acid is necessary
for attachment of
Ca++ which in turn allows the factor to bind with phospholipids
Mode of action of vitamin K:
Protein
S
Vitamin K antagonists:
In vitamin K deficiencies or coumadin therapy the factors synthesized lack g-carboxyglutamic acid and can’t participate in coagulation