Common Pathway
Cascade Theory of Coagulation-III
X
Xa
Prothrombin (II)
thrombin (IIa)
V
Va
Ca++
PF3
Fibrinogen (I)
Fibrin monomers
Fibrin polymers
XIII
XIIIa
Other
functions of thrombin:
Activates VIII to VIIIa
Activates XI to XIa
Inhibits plasminogen to plasmin conversion
Indirectly causes platelets to aggregate
prothrombinase complex
Stimulates release of TPA from endothelial cells