t-PA and PAI-1
Tissue Plasminogen Activators (t-PA):
Source:
When
bound to fibrin or fibrinogen they:
Factors
that can stimulate t-PA release:
Endothelial cells
Converts plasminogen to plasmin
Histamine, vasopressin, bradykinin, and adrenaline
Thrombin
Plasminogen Activator Inhibitor-1 (PAI-1):
Source:
Endothelial cells and platelets
Factors
that can stimulate PAI-1 release:
TPA
Thrombin