Liver
Disease - 2
Procoagulant dysfunction:
Fibrinogen – factor I:
Mechanisms for hemorrhagic episodes:
An acute phase protein
Elevated levels in
early-mild liver disease
Structurally abnormal
facto I produced which is nonfunctional “dyfibrinogenemia”
Thrombin Time (TT)
Reptilase test
Coagulation tests that
will be prolonged:
Thrombocytopenia is
common (<100 x 109/L)
Platelet abnormalities:
Cause:
Shortened half-life,
increased sequestration, alcohol suppresses bm, secretion & aggregation abnormal
