Therapy
in Liver Disease
Increase procoagulants that are
vitamin K dependent:
Vitamin K:
II, VII, IX, and X
Protein C
Protein S
Typical dose:
Fresh Frozen Plasma (FFP):
10 mL/kg body weight
600 – 2000 mL initial
dose (3 – 4 units)
Cryoprecipitate (Cryo):
One of choice to prevent volume
overload for high factor I replacement
Risk of viral transmission:
1 in 700,000 units may be positive
