Nephrotic Syndrome
Mechanism of hemorrhage:
Increased glomerular permeability associated with:
Chronic glomerularnephritis
Diabetic glomerulosclerosis
SLE
amyloidosis
Renal vein thrombosis
Low molecular weight proteins are lost to urine
Outcome:
Most of the time (75%) the loss of procoagulants leads to bleeding
25% of time loss of coagulant regulators leads to thrombosis