Vitamin K factor abnormalities
Detection of vitamin K deficiency or PIVKA:
Prolonged Prothrombin Time (PT) assay
Prolonged activated Partial Thromboplastin Time (aPTT) assay
Therapy:
Both assays corrected by mixing normal plasma with patient plasma
Individual factor assays reveal deficiency in vitamin K dependent factors
Oral or parenteral doses of vitamin K
To stop severe hemorrhage FFP or Prothrombin complex concentrate (II, VII, IX, and X) may be given