Acquired
von Willebrand Disease
Mechanisms:
Antibodies that are specific for an
vWF binding epitope on factor VIII
vWF absorbed onto abnormal cell
surfaces
Seen in association with:
Autoimmune disorders
Lymphoproliferative disorders
Myeloproliferative disorders
Benign monoclonal gammopathies
Wilms tumor (kidney tumor in
children <5 years old)
Intestinal angiodysplasia
Congenital heart disease
Pesticide exposure
HUS
