Congenital
von Willebrand Disease-1
Incidence:
Most prevalent congenital bleeding
disorder
Abnormal vWF results in abnormal
platelet adhesion
and aggregation
Symptoms:
Factor VIII binding (Factor VIII
survives longer)
Platelet glycoprotein Ib/IX –
activates platelet
Platelet glycoprotein IIb/IIIa –
also binds factor I
Collagen binding
Most common in group O blood types
Four binding domains to vWF: