Congenital
von Willebrand Disease-3
Subtype 2A
Autosomal dominant
vWF disease types & subtypes (cont’d):
10 – 20% of cases
vWF susceptible to
destruction
Abnormal platelet
aggregation
Subtype 2B
Rare mutations results
in:
Increased affinity of
vWF for gp Ib/IX causes platelet clumping and no vWF for platelet adhesion
“platelet type” or
“pseudo-vWF disease” is where gp Ib/IX has increased affinity for normal vWF
