Congenital
von Willebrand Disease-4
Subtype 2M
Rare variant
vWF disease types & subtypes (cont’d):
Decreased platelet
binding
Often misdiagnosed as
type 1
Subtype 2N
Autosomal mutation
Also called “Normandy
variant” or “autosomal hemophilia”
Abnormal binding of VIII
results in decreased VIII in both males and females
Type 3
Autosomal recessive
Rare
Both vWF and VIII
decreased – looks like Hemophilia A
