Therapy in vW
Pressure and ice packs
Mild hemorrhage:
Estrogen + DDAVP (desmopressin acetate):
Target is 75% vWF levels
Effective in type 1 vW
Variable effect in subtype 2A
Should not be given in subtype 2B
Subtypes 2A, 2B and type 3
Multiple hemorrhages:
Factor VIII concentrates
Severe vWF deficiencies:
Should not give FFP or cryoprecipitate
1 in 700,000 chance of viral
contamination