Hemophilia
A - 1
Factor VIII
Procoagulant deficiency:
Gene is located on chromosome:
X
Factor VIII is carried by vWF
Short half-life if not
bound to vWF
Factor VIII binds with:
Factor VIII
characteristics:
Phospholipid + IXa to
form:
“tenase complex”
Deteriorates at a rate of 5% per
hour at room temperature
Factor X – start of
common pathway
Tenase complex activates:
Action is Ca++ dependent
