Hemophilia A - 2
Sex-linked recessive on X chromosome
Genetics:
Male:
Bleeding episodes
Heterozygous will show:
Female:
Disease manifestations:
Heterozygous:
Normal male has children with heterozygous female:
“silent carrier”
Homozygous:
May show bleeding episodes
Offspring:
X
Y
X
X
h
XX
XY
XX
h
X
h
Y
Male
Female