CLSC412 HEMOSTASIS

VIII Inhibitors in Hemophilia A - 1

Failure to achieve a rise in VIII activity following injection of VIII concentrate

Detection of inhibitors:

IgG4

Class of immunoglobulin:

1 mL of patient plasma mixed with 1 mL of normal plasma and aPTT repeated following 2 hour incubation.

Lab detection of inhibitor:

If aPTT is corrected – no inhibitor

If aPTT is uncorrected – Lupus anticoagulant

1 mL of patient plasma mixed with 1 mL of normal plasma and aPTT repeated immediately:

If aPTT is corrected – no inhibitor

If aPTT is uncorrected – inhibitor