Diseases
& Risk Factors - 1
Anti-phospholipid antibodies may be
associated with SLE
30% of pts with APL antibodies
develop either arterial or venous thrombosis
Autoimmune disorders:
Thrombotic episodes may be due to
either:
Myeloproliferative
disorders:
Hepatic/renal
disorders:
ET and PV may have platelet
activation due to increased viscosity of blood
Decreased production of
coagulation control proteins
Increased loss of
coagulation control proteins
PNH – mutation in stem cell results
in loss membrane-anchored platelet activation suppressors with 40% or more PNH pts developing thrombosis
