Fibrinogen
(Factor I) - 1
Strong predictor of CVD risk:
Predictor value:
Positive correlation with
risk of MI in patients with angina pectoris as well as normal patients
High I + high
Cholesterol = high risk of MI
No therapeutic means of lowering
factor I levels by itself. It is lowered by exercise, cholesterol lowering drugs, and quitting smoking
Low I + high
Cholesterol = low risk of MI
Why it isn’t
used as Predictor of MI:
Thus no clinical trials to prove
lowering factor I levels lowers risk of MI
Fibrinogen assays are
non-standardized
