Aspirin
Therapy Monitoring - 2
Tests used to monitor aspirin effect: cont’d
platelets
11-hydroxythromboxane dehydrogenase
(hepatocyte)
11-Dehydro TXB2 levels:
Plasma TXB2 11-Dehydro TXB2
Aspirin therapy
So
urinary levels of 11-Dehydro TXB2 reflect platelet activity
Elevated
levels seen in:
artherosclerosis
CVA & Transient
ischemic attack
Intracerebral hemorrhage
& atrial fibrillation
Cleared by kidneys
Decreased
levels seen in:
