Antithrombin
Deficiencies
Liver disease
Acquired deficiencies associated with:
Prolonged heparin therapy
Congenital
deficiencies of antithrombin:
Nephrotic syndrome
L-asparaginase therapy
Seen in 0.2% of the population
Accounts for 2 – 5% of recurrent
venous thromboembolic
diseases
Type 1 = quantitative
deficiency (amount)
Oral contraceptives
D.I.C.
Type 2 = qualitative
deficiency (function)
Methods used
to measure antithrombin:
Latex microparticle immunoassay
(quantitation)
Clot/chromogenic assay (functional)
