Pathophysiology
of D.I.C.
Circulating
thrombin converts fibrinogen to fibrin
Coagulation control proteins are consumed in the process
Platelets
are activated by thrombin
Fibrinolytic
system activated and FDPs:
fibrinogen
Thrombin
Overview of process:
Fibrin monomers
Fibrin
polymers
XIIIa
FDPs act as anticoagulant agents
Have an anticoagulant effect
Activates plasminogen to plasmin
Plasmin then does the following:
Fibrinopeptide A and B
Cross-linked Fibrin polymers
