Immune
Drug-induced - 2
Mechanisms
involved:
Type 1:
Drug induces antibody
formation and antibodies attach to platelet by FAB portion when drug is present. Fc
portion then attaches to phagocytic cell
platelet
Phagocyte
antibody
drug
Mainly IgG may be IgM also
<10.0 x 109/L
Abrupt onset
Quinidine &
quinine