TTP
- continued
Lab features:
Severe intravascular hemolysis
Hgb <10.0 g/dL
Blood smear:
Decreased platelets
polychromasia
schistocytes
Haptoglobin - decreased
Hemosiderinuria & hemoglobinuria
- present
Unconjugated bilirubin - increased
Lactate dehydrogenase (LD) -
increased
Therapy:
Plasma exchange using FFP
FFP + corticosteroids
Prognosis:
Prior to 1990 – 80% died
Now 20% die