HUS
– Adult form
Immunosuppressive and/or
chemotherapeutic agents
Pregnancy
Renal arterial endothelial cell
damaged by therapeutic agent causes release of vWF multimers causing platelet aggregation
Causative
agents:
In pregnancy & oral
contraceptives the patient may form autoantibodies to endothelial cells
Mechanism:
Renal impairment requires dialysis
E. Coli can cause HUS in both children
& adults
Oral contraceptives
Features: