Drugs
Ristocetin - antibiotic
Protamine sulfate
Drugs that can
cause thrombocytopenia:
bleomycin
Mechanisms:
Causes vWF to bind with
GPIb on platelet resulting in platelet aggregation and thus removal by RES
Hematin, protamine sulfate, and
bleomycin:
Ristocetin:
Hematin – therapy for porphyrias
Causes platelet secretion
and aggregation