Drugs affecting Membranes - 1
Used to decrease risk of thrombosis-induced strokes in patients with CVD that can’t
tolerate aspirin
Ticlopidine:
Now
used for a variety of disorders
Inhibits ADP from binding with receptors so platelet aggregation to ADP and collagen
reduced
Receptor
for fibrinogen attachment to platelet
Inhibits
aggregation
GPIIb/IIIa receptor inhibitors:
Two
types of drugs:
Fab fragments that bind to receptor
Synthesized segment of fibrinogen that binds to receptor