Disorders & Platelet Function - 2
Platelets damaged or activated passing through pumps and tubing
Cardiopulmonary
bypass surgery:
Hypothermia
may also activate platelets
Liver disease:
hypersplenism
Toxic effects of alcohol
In chronic liver disease there may be mild – moderate thrombocytopenia due to:
Platelet
adhesion and aggregation abnormal
Platelet
factor 3 may be decreased
Uremia:
Dialyzable
products that affect platelet function:
Guanidinosuccinic acid
Hydroxyphenolic acid