Platelet
Aggregating Agonists - 1
Thrombin:
Induces full secretion and
aggregation
Storage pool disorders
Unaffected in these disorders:
Deminished secretion seen in:
Pathway enzyme
deficiencies
Most commonly used agonist
Membrane disorders
Low ADP (1 mM) induces “monophasic” aggregation:
Adenosine
Diphosphate (ADP):
Primary aggregation:
Reversible shape
change
High ADP (10 mM) induces “biphasic” aggregation:
Primary + Secondary
aggregation:
Irreversible shape
change, secretion, and aggregation