Platelet
Aggregating Agonists - 2
Aggregation diminished in:
Adenosine Diphosphate (ADP): (cont’d)
Membrane disorders
Cyclo-oxygenase
pathway enzyme deficiencies
Nonsteroidal
anti-inflammatory drugs like aspirin
Storage pool disorders
– not diminished if high ADP levels used
Epinephrine:
Binds with receptors on platelet
membrane causing
ADP to be secreted
Get same results as with ADP as
agonist except:
Epinephrine can’t
induce aggregation in:
Storage pool disorders
Secretion defects
10% of normal
platelets