aPTT
mixing studies - 1
Confirmation of circulating
anticoagulant/inhibitors in patient plasma causing prolonged aPTT
Purpose of studies:
Antibodies against
phospholipid-protein complexes
A non-specific inhibitor:
Factors affected:
May be formed due to factor
concentrates being given to patients with congenital factor deficiency
X, IX, and II all
require PF3 for activation
Most common factor inhibitor:
Anti-factor VIII (also
seen in autoimmune disorders and post-partum bleeding syndrome)
Lupus
anticoagulant:
Specific
inhibitors: