Department of
Biology

Peter Lyons: Publications

Refereed Papers

  1. Fajardo, D., Saint Jean, R., Lyons, P.J. (2023) Acquisition of new function through gene duplication in the metallocarboxypeptidase family. Scientific Reports. 13:2512. doi.org/10.1038/s41598-023-29800-9.
  2. Lyons, P.J. (2022) Isolation and functional analysis of a pancreatic enzyme in an introductory student lab. CourseSource. 9:doi.org/10.24918/cs.2022.39.
  3. Bauza Nowotny, E., Lyons, P.J., Gonzalez-Socoloske, D. (2022) Identification of the Eastern Massasauga Rattlesnake (Sistrurus catenatus) through genetic analysis of shed skin. Conservation Genetics Resources. 14(3):291-297.
  4. McDonald RC, Schott MJ, Idowu TA, Lyons PJ (2020). Biochemical and genetic analysis of Ecm14, a conserved fungal pseudopeptidase. BMC molecular and cell biology. 21(1):1-6.
  5. Burke, L.C., Ezeribe, H.O., Kwon, A.Y., Dockery, D., Lyons, P.J. (2018) Carboxypeptidase O is a lipid droplet-associated enzyme able to cleave both acidic and polar C-terminal amino acids. PLoS ONE. 13(11):e0206824. doi: 10.1371/journal.pone.0206824.
  6. Garcia-Guerrero, M.C., Garcia-Pardo, J., Berenguer, E., Fernandez-Alvarez, R., Barfi, G.B., Lyons, P.J., Aviles, F.X., Huber, R., Lorenzo, J., Reverter, D. (2018) Crystal structure and mechanism of human carboxypeptidase O: Insights into its specific activity for acidic residues. Proc Natl Acad Sci U S A. 115:E3932-E3939. 
  7. Lyons, P.J., Sapio, M.R., Fricker, L.D. (2013) Zebrafish cytosolic carboxypeptidases 1 and 5 are essential for embryonic development. J. Biol. Chem. 288:30454-30462.
  8. Berezniuk, I., Lyons, P.J., Sironi, J.J., Xiao, H., Setou, M., Angeletti, R.H., Ikegami, K., Fricker, L.D. (2013) Cytosolic carboxypeptidase 5 removes α- and γ-linked glutamates from tubulin. J. Biol. Chem. 288:30445-30453.
  9. Sapio, M.R., Salzmann, A., Vessaz, M., Crespel, A., Lyons, P.J., Malafosse, A., Fricker, L.D. (2012) Naturally occurring carboxypeptidase A6 mutations: effect on enzyme function and association with epilepsy. J. Biol. Chem. 287:42900-9..
  10. Berezniuk, I., Vu, H.T., Lyons, P.J., Sironi, J.J., Xiao, H., Burd, B., Setou, M., Angeletti, R.H., Ikegami, K., Fricker, L.D. (2012) Cytosolic carboxypeptidase 1 is involved in processing as α- and β-tubulin. J. Biol. Chem. 287: 6503-17.
  11. Salzmann, A., Guipponi, M., Lyons, P.J., Fricker, L.D., Sapio, M., Lambercy, C., Buresi C., Bencheikh, B.O.A., Lahjouji, F., Ouazzani, R., Crespel, A., Chaigne, D. and Malafosse, A. (2012) Carboxypeptidase A6 gene (CPA6) mutations in a recessive familial form of febrile seizures and temporal lobe epilepsy and in sporadic temporal lobe epilepsy. Human Mutation. 33: 124-35. doi: 10.1002/humu.21613
  12. Lyons, P.J. and Fricker, L.D. (2011) Carboxypeptidase O is a glycosylphasphatidylinositol-anchored intestinal peptidase with acidic amino acid specificity. J. Biol. Chem. 286:39023-32.
  13. Lyons, P.J. and Fricker, L.D. (2011) Peptidomic approaches to study proteolytic activity. Current Protocols in Protein Science, 65:18.13.1-18.13.12.
  14. Lyons, P.J. and Fricker, L.D. (2010) Substrate specificity of human carboxypeptidase A6. J. Biol. Chem. 285, 38234-42.
  15. Lyons, P.J., Ma, L., Baker, R., and Fricker, L.D. (2010) Carboxypeptidase A6 in zebrafish development and implications for VIth cranial nerve pathfinding. PLoS ONE 5(9): e12967. doi:10.1371/journal.pone.0012967
  16. Lyons, P.J., Callaway, M.B., and Fricker, L.D. (2008) Characterization of carboxypeptidase A6, an extracellular-matrix peptidase. J. Biol. Chem. 283, 7054-63.
  17. Ro, H.-S., Zhang, L., Majdalawieh, A., Kim, S.-W., Wu, X., Lyons, P.J., Webber, C., Ma, H., Reidy, S.P., Boudreau A., Miller, J.R., Mitchell, P. and McLeod, R.S.  (2007) Adipocyte enhancer-binding protein 1 modulates adiposity and energy homeostasis.  Obesity. 15, 288-302.
  18. Lyons, P.J., Mattatall, N.M., and Ro, H.-S. (2006) Modeling and functional analysis of AEBP1, a transcriptional repressor. Proteins. 63, 1069-83.
  19. Lyons, P.J., Muise, A.M., and Ro, H.-S. (2005) MAPK modulates the DNA binding of adipocyte enhancer-binding protein 1. Biochemistry. 44, 926-31.
  20. Kim, S.-W., Muise, A.M., Lyons, P.J., and Ro, H.-S. (2001) Regulation of adipogenesis mediated by a transcriptional repressor that modulates MAPK.    J. Biol. Chem.  276, 10199-10206.

Book Chapters

  1. Fricker, L.D. and Lyons, P.J. (2013) Carboxypeptidase A6. In: Handbook of Proteolytic Enzymes, Third Edition (Rawlings, N.D. and Salvesen, G.S., editors) Oxford: Academic Press, pp. 1318-1321.
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