2025-2026 Faculty Research Grants

Marlene Murray (Biology). 

Expression of RASGRP1 Protein in Bipolar Derived Lymphoblastoids.

Bipolar disorder (BD) presents a significant public health challenge, characterized by recurrent episodes of mania and depression. Its complex etiology involves both genetic predisposition and environmental factors; however, the molecular mechanisms underlying BD remain incompletely understood. Recent advances in genetic research have identified RASGRP1, a gene implicated in immune function and inflammatory responses, as a potential  contributor to BD pathogenesis. However, gaps remain in our understanding of RASGRP1 expression patterns in BD cell lines and its response to mood-related stimuli, such as the stress hormone cortisol.

To address this gap, the proposed research aims to elucidate the relationship between RASGRP1 and BD using lymphoblastoid cell lines (LCLs). The study will compare the Rasgrp1 protein (the product of the RASGRP1 gene) expression levels across BD I, BD II, and neurotypical LCLs using western blot  analysis. Additionally, the study will assess the effect of cortisol on RASGRP1 expression by exposing cell cultures to cortisol treatment and evaluating subsequent expression changes. By investigating RASGRP1 expression and its responsiveness to stress hormones, this research may provide valuable insights into the molecular mechanisms contributing to BD.